The destructive capabilities of natural hazards, coupled with their far-reaching consequences on employment, health, population migrations, and poverty perpetuation, are well-recognized. The People’s Republic of China faces a wide array of natural hazards, and these challenges are exacerbated by climate change and rapid urbanization. The interconnectedness of urban systems makes them highly vulnerable to cascading effects from disasters. Meanwhile, rural areas, where many young and older residents remain due to rural-to-urban migration, are also at risk. Disaster Risk Management is crucial, but it requires tailored solutions that consider geographic, social, and economic factors. Cost-effectiveness principles are essential to prioritize impactful measures, benefiting both the country and the region. Collaboration with neighboring countries is vital for promoting regional disaster resilience, as natural hazards show no signs of abating, necessitating immediate adaptation and preparation.